Yes.
Some computers, such as the Digital Equipment Corporation (DEC) Vax, have specialized call and return machine instructions. But experimentally these add little to performance. The general purpose instructions of a reduced instruction set proved to be faster.
Here is an example program: the program is to read in lines of text from the user. Lower case characters from each line are converted to upper case. The user quits the program by entering a single character 'Q' at the start of a line.